Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic form of coronary artery disease of unknown cause that predominantly affects women (>90%; mean age 44-55 years) and can be fatal. The finding of familial clustering, including the concordant involvement of monozygotic twins and its association with the PHACTR1/EDN1 genetic locus, indicates a genetic predisposition to its pathophysiology. Human-induced pluripotent stem cell lines (hiPSCs) were generated from patients who had survived an episode of SCAD. The cells generated using non-integrative Sendai virus and show expression of all pluripotency markers, the ability to differentiate into three germ layers and are genetically stable. These disease-specific hiPSC lines along with their healthy control cell lines will be useful for the study of SCAD after differentiation into blood vessel-forming cells.